NSC-88915

NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative[1][2].

Product Specifications

CAS Number

[21170-34-3]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

O=S(C1=CC=C(C=C1)Br)(OCC([C@H]2CC[C@]3([C@@]4(CCC5=CC(CC[C@@]5([C@]4(CC[C@]23C)[H])C)=O)[H])[H])=O)=O

Molecular Formula

C27H33BrO5S

Molecular Weight

549.52

References & Citations

[1]Dexheimer, T. S., et al., (2009) . 4-Pregnen-21-ol-3,20-dione-21- (4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of medicinal chemistry, 52 (22), 7122-7131.|[2]Nguyen, T. X., et al., (2012) . Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1) -topoisomerase I (Top1) inhibitors. Journal of medicinal chemistry, 55 (9), 4457-4478.