W2476

W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1) . W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model[1][2].

Product Specifications

CAS Number

[432016-77-8]

UNSPSC

12352005

Target

Others

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C(C)C1=CC=C(C=C1)OCCN2C=NC3=C2N=CN=C3N

Molecular Formula

C15H15N5O2

Molecular Weight

297.31

References & Citations

[1]Li, T., et al., (2017) . W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica, 38 (7), 1024-1037.|[2]Zhong, L., et al., (2021) . W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319. Chemical biology & drug design, 97 (5), 1089-1099.