W2476
W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1) . W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model[1][2].
Product Specifications
CAS Number
432016-77-8
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(C)C1=CC=C(C=C1)OCCN2C=NC3=C2N=CN=C3N
Molecular Formula
C15H15N5O2
Molecular Weight
297.31
References & Citations
[1]Li, T., et al., (2017) . W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica, 38 (7), 1024-1037.|[2]Zhong, L., et al., (2021) . W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319. Chemical biology & drug design, 97 (5), 1089-1099.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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