Epiallopregnanolone-d5

Epiallopregnanolone-d5 (5α,3β-THDOC-d5) is deuterium labeled Epiallopregnanolone. Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer[1].

Product Specifications

Product Name Alternative

5α,3β-THDOC-d5

UNSPSC

12352211

Target

GABA Receptor; iGluR; Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

C[C@@]12[C@]([C@]3([H])CC[C@@]4([H])C([2H])([2H])[C@](O)([2H])C([2H])([2H])C[C@]4(C)[C@@]3([H])CC1)(CC[C@@H]2C(CO)=O)[H]

Molecular Formula

C21H29D5O3

Molecular Weight

339.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Brett C Ginsburg, et al. Alphaxalone and epiallopregnanolone in rats trained to discriminate ethanol. Alcohol Clin Exp Res. 2005 Sep;29 (9) :1621-9.