5F-203 (Standard)

5F-203 (Standard) is the analytical standard of 5F-203. This product is intended for research and analytical applications. 5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].

Product Specifications

CAS Number

[260443-89-8]

UNSPSC

12352100

Target

Aryl Hydrocarbon Receptor; Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Others

Smiles

NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C

Molecular Formula

C14H11FN2S

Molecular Weight

258.32

References & Citations

[1]Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2- (4-aminophenyl) benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45 (3) :744-7. |[2]Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2 (12) :1265-72.|[3]Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2- (4-amino-3-methylphenyl) -5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114 (10) :2392-404.