4'-Hydroxytamoxifen (TFA) (Standard)

4'-Hydroxytamoxifen (TFA) (Standard) is the analytical standard of 4'-Hydroxytamoxifen (TFA) . This product is intended for research and analytical applications. 4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells[1].

Product Specifications

UNSPSC

12352005

Target

Drug Metabolite; Estrogen Receptor/ERR; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3.OC(C(F)(F)F)=O

Molecular Formula

C28H30F3NO4

Molecular Weight

501.54

References & Citations

[1]Cuevas M E, et al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B[J]. Oncology Reports, 2015, 33 (1) : 464-470.