GL-1196

GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research[1][2].

Product Specifications

CAS Number

[591242-70-5]

UNSPSC

12352005

Target

PAK

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=S1(N=C(N(CC2=C(O)C=CC=C2)C3=CC=C(C=C3)Cl)C4=C1C=CC=C4)=O

Molecular Formula

C20H15ClN2O3S

Molecular Weight

398.86

References & Citations

[1]Huang, G., et al., (2025) . P21-activated kinase 4: a potent oncogene, molecular mechanisms and opportunities for targeted therapy. Cancer cell international, 25 (1), 409.|[2]Zhang, J., et al., (2024) . Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470. International journal of molecular sciences, 25 (24), 13456.