DBCO-NHCO-PEG4-amine (TFA)
DBCO-NHCO-PEG4-amine TFA is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine TFA is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].
Product Specifications
UNSPSC
12352005
Target
ADC Linker; PROTAC Linkers
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Field of Research
Cancer
Purity
96.74
Smiles
O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCOCCOCCN)=O.O=C(O)C(F)(F)F
Molecular Formula
C31H38F3N3O8
Molecular Weight
637.64
References & Citations
[1]Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15 (5) :2054-2059.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers
Available Sizes
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