SP-141 (hydrochloride)
SP-141 (hydrochloride) is a specific inhibitor of MDM2. SP-141 (hydrochloride) promotes MDM2 auto-ubiquitination and degradation. SP-141 (hydrochloride) might be used for the research of pancreatic cancer and breast cancer cells[1][2].
Product Specifications
CAS Number
[56501-26-9]
UNSPSC
12352005
Target
MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCCN1CCCCC1)OC2=C3C(CC(C)CC4)=C4C(C)(C)OC3=CC(C(C)C(C)CCCCC)=C2.Cl
Molecular Formula
C34H54ClNO3
Molecular Weight
560.25
References & Citations
[1]Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147 (4) :893-902.e2. |[2]Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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