Carotegrast methyl (hydrochloride)
Carotegrast methyl (AJM300) hydrochloride is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl hydrochloride, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl hydrochloride prevents the development of colitis in mice[1].
Product Specifications
CAS Number
1338380-52-1
Product Name Alternative
AJM300 (hydrochloride)
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Inflammation/Immunology
Smiles
O=C([C@@H](NC(C1=C(C=CC=C1Cl)Cl)=O)CC2=CC=C(C=C2)N3C(N(C4=C(C3=O)C=C(C=C4)N(C)C)C)=O)OC.Cl.[x]
Molecular Formula
C28H26Cl2N4O5.xHCl
Molecular Weight
569.44 (free base)
References & Citations
[1]Toshihiko Sugiura, et al. Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis. 2013 Dec;7 (11) :e533-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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