ADM 12
ADM 12 is a highly selective transient receptor potential ankyrin 1 (TRPA1) channel antagonist. ADM 12 blocks nitroglycerin (NTG) -induced trigeminal hyperalgesia in animal models, reducing expression of pain-related genes (c-Fos, TRPA1) and neuropeptides (CGRP, SP) . ADM_12 is promising for research of migraine and neuropathic pain[1].
Product Specifications
CAS Number
1644134-60-0
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S(CCCNC(CCCCC1SSCC1)=O)(O)=O
Molecular Formula
C11H21NO4S3
Molecular Weight
327.48
References & Citations
[1]Demartini C, et al. The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. J Headache Pain. 2017 Sep 7;18 (1) :94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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