42- (2-Tetrazolyl) rapamycin

42- (2-Tetrazolyl) rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

Product Specifications

CAS Number

[221877-56-1]

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

95.78

Solubility

DMSO : ≥ 130 mg/mL

Smiles

[H][C@]1(C(O[C@@]([C@@H](C[C@H]2C[C@@H](OC)[C@@H](N3N=CN=N3)CC2)C)([H])CC([C@@H](/C=C([C@@H](O)[C@H]4OC)\C)C)=O)=O)N(C(C([C@@]5(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C4=O)OC)([H])O5)=O)=O)CCCC1

Molecular Formula

C52H79N5O12

Molecular Weight

966.21

References & Citations

[1]Karl W. Mollison, et al. Compounds and methods for treatment and prevention of diseases. US 20080171763 A1.|[2]Ballou LM, et al. Rapamycin and mTOR kinase inhibitors. J Chem Biol. 2008 Nov;1 (1-4) :27-36.