JNJ-47117096
JNJ-47117096 is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM[1].
Product Specifications
CAS Number
1610586-62-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
FLT3; MELK
Related Pathways
PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(CCNCC2)C2=C1)C3=CC=C(C4=CNN=C4)C=C3OC
Molecular Formula
C21H22N4O2
Molecular Weight
362.43
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6 (1) :25-30.|[2]Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35 (6) . pii: e00267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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