JNJ-47117096

JNJ-47117096 is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM[1].

Product Specifications

CAS Number

[1610586-62-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

FLT3; MELK

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(CCNCC2)C2=C1)C3=CC=C(C4=CNN=C4)C=C3OC

Molecular Formula

C21H22N4O2

Molecular Weight

362.43

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Johnson CN, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. ACS Med Chem Lett. 2014 May 23;6 (1) :25-30.|[2]Beke L, et al. MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Rep. 2015 Oct 2;35 (6) . pii: e00267.