EC-70124
EC-70124 is an orally active multikinase inhibitor targeting IKKβ and JAK2. EC-70124 blocks IkB phosphorylation and STAT3 (Tyr705) activation, suppressing NF-κB nuclear translocation and STAT3 transcriptional activity. EC-70124 reduces tumor growth and cancer stem cell (CSC) populations in prostate cancer cells and xenograft models. EC-70124 is promising for research of prostate cancer[1].
Product Specifications
CAS Number
1185908-92-2
UNSPSC
12352005
Target
IKK; JAK; NF-κB; STAT
Related Pathways
Epigenetics; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)=O)=C6C7=C4N([C@](C[C@@H]([C@H]2O)O)([H])O1)C8=CC=CC=C78
Molecular Formula
C26H19N3O5
Molecular Weight
453.45
References & Citations
[1]Civenni G, et al. EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB. Mol Cancer Ther. 2016 May;15 (5) :806-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
IKK-β; JAK2; NF-κB; STAT3
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