ML 086

ML 086 is a highly selective PHOSPHO1 phosphatase inhibitor (IC50=0.14 μM) . ML 086 is promising for research of hereditary vascular calcification disorders (e.g., generalized arterial calcification of infancy) and spinal ligament ossification[1].

Product Specifications

CAS Number

[1177148-36-5]

UNSPSC

12352005

Target

Phosphatase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

O=C(N(C)C)C1=CC=CC(N2SC3=C(C=CC=C3)C2=O)=C1

Molecular Formula

C16H14N2O2S

Molecular Weight

298.36

References & Citations

[1]Bravo Y, et al. Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorg Med Chem Lett. 2014 Sep 1;24 (17) :4308-11.