ML 086
ML 086 is a highly selective PHOSPHO1 phosphatase inhibitor (IC50=0.14 μM) . ML 086 is promising for research of hereditary vascular calcification disorders (e.g., generalized arterial calcification of infancy) and spinal ligament ossification[1].
Product Specifications
CAS Number
1177148-36-5
UNSPSC
12352005
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N(C)C)C1=CC=CC(N2SC3=C(C=CC=C3)C2=O)=C1
Molecular Formula
C16H14N2O2S
Molecular Weight
298.36
References & Citations
[1]Bravo Y, et al. Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1. Bioorg Med Chem Lett. 2014 Sep 1;24 (17) :4308-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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