Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Talfirastide (Standard)

Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang- (1-7) ) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM) . Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].

Product Specifications

CAS Number

51833-78-4

UNSPSC

12352209

Target

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Endocrinology; Cancer

Smiles

O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@@]([C@@H](C)CC)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC=N3

Molecular Formula

C41H62N12O11

Molecular Weight

899.00

References & Citations

[1]Gómez-Mendoza DP, et al. Angiotensin- (1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486.|[2]Li P, et al. Angiotensin- (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29 (1 Pt 2) :394-400.|[3]Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11 (3) :e0150861.|[4]Alzayadneh EM, et al. Angiotensin- (1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568 (14) 00314-3.|[5]Janatpour ZC, et al. Subcutaneous Administration of Angiotensin- (1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36 (22) :3115-3131.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Rat Monoclonal IFN-gamma R1/CD119 Antibody (RM0093-7K23) [PE]
NBP1-22408PE 0.1 mL

Rat Monoclonal IFN-gamma R1/CD119 Antibody (RM0093-7K23) [PE]

Sign In for Pricing
View Details
P-cadherin Rabbit Polyclonal Antibody (HRP)
orb482822 100 µL

P-cadherin Rabbit Polyclonal Antibody (HRP)

Sign In for Pricing
View Details
NPHS1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV678664 1.0 µg DNA

NPHS1 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

Sign In for Pricing
View Details
GRINA Rabbit pAb
MBS9142298-01 0.02 mL

GRINA Rabbit pAb

Sign In for Pricing
View Details
GRINA Rabbit pAb
MBS9142298-02 0.1 mL

GRINA Rabbit pAb

Sign In for Pricing
View Details
GRINA Rabbit pAb
MBS9142298-03 5x 0.1 mL

GRINA Rabbit pAb

Sign In for Pricing
View Details