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Talfirastide (Standard)

Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang- (1-7) ) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM) . Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].

Product Specifications

CAS Number

51833-78-4

UNSPSC

12352209

Target

Angiotensin Receptor; Angiotensin-converting Enzyme (ACE) ; Endogenous Metabolite; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Endocrinology; Cancer

Smiles

O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@@]([C@@H](C)CC)([H])NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)CC3=CNC=N3

Molecular Formula

C41H62N12O11

Molecular Weight

899.00

References & Citations

[1]Gómez-Mendoza DP, et al. Angiotensin- (1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4. J Proteomics. 2019;208:103486.|[2]Li P, et al. Angiotensin- (1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide. Hypertension. 1997 Jan;29 (1 Pt 2) :394-400.|[3]Khajah MA, et al. Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis. PLoS One. 2016 Mar 10;11 (3) :e0150861.|[4]Alzayadneh EM, et al. Angiotensin- (1-7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2. Cell Signal. 2014 Sep 19. pii: S0898-6568 (14) 00314-3.|[5]Janatpour ZC, et al. Subcutaneous Administration of Angiotensin- (1-7) Improves Recovery after Traumatic Brain Injury in Mice. J Neurotrauma. 2019;36 (22) :3115-3131.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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