BR101549

BR101549 is a non-TZD agonist of PPARγ. BR101549 activates PPARγ to the level of Pioglitazone in vitro. BR101549 can control blood glucose level in mouse model. BR101549 can be studied in anti-diabetic research[1].

Product Specifications

CAS Number

[2252478-54-7]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C(OCC)CC1=C(C(C)C)N=C(CCCC)N(CC2=CC=C(C3=CC=CC=C3C(N4)=NOC4=O)C=C2)C1=O

Molecular Formula

C30H34N4O5

Molecular Weight

530.61

References & Citations

[1]Choung, W., et al., (2019) . Identification of BR101549 as a lead candidate of non-TZD PPARγ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorganic & medicinal chemistry letters, 29 (4), 631-637.