ISO-92

ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research[1][2].

Product Specifications

CAS Number

899433-49-9

UNSPSC

12352005

Target

Macrophage migration inhibitory factor (MIF)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(OCC(C)(C)C)C[C@H]1CC(C2=CC=C(O)C(F)=C2)=NO1

Molecular Formula

C16H20FNO4

Molecular Weight

309.33

References & Citations

[1]Perveen, S., et al., (2019) . MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia. Pediatric research, 85 (5), 711-718. |[2]Zhang, Y., et al., (2012) . Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Molecular medicine (Cambridge, Mass.), 18 (1), 215-223.