ISO-92
ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research[1][2].
Product Specifications
CAS Number
[899433-49-9]
UNSPSC
12352005
Target
Macrophage migration inhibitory factor (MIF)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(OCC(C)(C)C)C[C@H]1CC(C2=CC=C(O)C(F)=C2)=NO1
Molecular Formula
C16H20FNO4
Molecular Weight
309.33
References & Citations
[1]Perveen, S., et al., (2019) . MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia. Pediatric research, 85 (5), 711-718. |[2]Zhang, Y., et al., (2012) . Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Molecular medicine (Cambridge, Mass.), 18 (1), 215-223.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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