PF-06745013
PF-06745013 (Compound 37) is a MAP4K4 inhibitor without time-dependent inhibition (TDI) risk of CYP3A4 (IC50 of 0.4 nM for MAP4K4) . PF-06745013 has no accumulation CNS-impaired and non-ATP competitive activities in mouse models. PF-06745013 can be used for inflammatory diseases like diabetes and cancers research[1].
Product Specifications
CAS Number
2089334-01-8
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
MAP4K; TNF Receptor
Related Pathways
Apoptosis; MAPK/ERK Pathway
Field of Research
Cancer; Metabolic Disease
Smiles
O=C(C(C)(C)OC1=CC=C(C2=CN=C(C(C3=CC=C(Cl)C=C3)=C2)N)C=C1)O
Molecular Formula
C21H19ClN2O3
Molecular Weight
382.84
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61 (7) :3114-3125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK
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