Contilisant

Contilisant is a permeable antioxidant and neuroprotectant agent. Contilisant exhibits high nM affinity at H3R. Contilisant inhibits monoamine oxidases and cholinesterases. Contilisant has a binding affinity of 65.23 nM towards hS1R. Contilisant can significantly restore cognitive deficit induced by Aβ1-42 in the radial maze assay of Alzheimer’s animal model[1].

Product Specifications

CAS Number

[2135615-68-6]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Histamine Receptor; Monoamine Oxidase; Reactive Oxygen Species (ROS)

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Smiles

C#CCN(C)CC(N1C)=CC2=C1C=CC(OCCCN3CCCCC3)=C2

Molecular Formula

C22H31N3O

Molecular Weight

353.50

References & Citations

[1]Bautista-Aguilera, Ó. M., et al., (2018) . Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. Journal of medicinal chemistry, 61 (15), 6937-6943.