CSLP37
CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM. CSLP37 shows no inhibitory activity against RIPK1 and RIPK3. CSLP37 displays potent suppression of cellular NOD1 and NOD2 responses[1].
Product Specifications
CAS Number
2244984-64-1
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Smiles
CCCS(=O)(NC1=CC(C2=CC(C3=CC=C(N4CCNCC4)C=C3)=CN=C2N)=CC(F)=C1OC)=O
Molecular Formula
C25H30FN5O3S
Molecular Weight
499.60
References & Citations
[1]Matous Hrdinka, et al. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37 (17) :e99372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK2
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