CSLP37

CSLP37 is a selective RIPK2 inhibitor with an IC50 of 16.3 nM. CSLP37 shows no inhibitory activity against RIPK1 and RIPK3. CSLP37 displays potent suppression of cellular NOD1 and NOD2 responses[1].

Product Specifications

CAS Number

[2244984-64-1]

UNSPSC

12352005

Target

RIP kinase

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Smiles

CCCS(=O)(NC1=CC(C2=CC(C3=CC=C(N4CCNCC4)C=C3)=CN=C2N)=CC(F)=C1OC)=O

Molecular Formula

C25H30FN5O3S

Molecular Weight

499.60

References & Citations

[1]Matous Hrdinka, et al. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 Sep 3;37 (17) :e99372.