Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Lofepramine (Standard)

Lofepramine (Standard) is the analytical standard of Lofepramine. This product is intended for research and analytical applications. Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties.[2][3][4].

Product Specifications

CAS Number

23047-25-8

UNSPSC

12352100

Target

5-HT Receptor; Adrenergic Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=CC=CC=C3CCC4=CC=CC=C42

Molecular Formula

C26H27ClN2O

Molecular Weight

418.96

References & Citations

[1]Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37 (2) :123-40.|[2]Segawa T, et al. Effect of lofepramine and other antidepressants on the uptake of 5-hydroxytryptamine and noradrenaline into rat brain monoaminergic neurons. J Pharm Pharmacol. 1977 Mar;29 (3) :139-42.|[3]McIntyre RS, et al. The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects. Expert Opin Investig Drugs. 2017 Jun;26 (6) :767-770. |[4]Kelly JP, et al. An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur Neuropsychopharmacol. 1999 Jan;9 (1-2) :101-5.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Recombinant Caveolin-3 Monoclonal Antibody
AN301915L-01 50 µL

Recombinant Caveolin-3 Monoclonal Antibody

Sign In for Pricing
View Details
Recombinant Caveolin-3 Monoclonal Antibody
AN301915L-02 100 µL

Recombinant Caveolin-3 Monoclonal Antibody

Sign In for Pricing
View Details
Human ARP10 (APOBEC3H) activation kit by CRISPRa
GA116115 1 Kit

Human ARP10 (APOBEC3H) activation kit by CRISPRa

Sign In for Pricing
View Details
Histone H1 (Pan Nuclear Marker) (AE-4), CF568 conjugate, 0.1mg/mL
BNC683325-500 1x 500 µL

Histone H1 (Pan Nuclear Marker) (AE-4), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Rex1 (ZFP42) Mouse Monoclonal Antibody [Clone ID: OTI3B2]
CF807870 100 µg

Rex1 (ZFP42) Mouse Monoclonal Antibody [Clone ID: OTI3B2]

Sign In for Pricing
View Details
3-Chloroperbenzoic Acid (Technical Grade, wet with water)
TRC-C374915-25G 25 g

3-Chloroperbenzoic Acid (Technical Grade, wet with water)

Sign In for Pricing
View Details