VK4-116
VK4-116 (Compound 19) is a selective Dopamine D3 receptor (D3R) antagonist with a Ki of 6.84 nM.VK4-116 significantly inhibits Oxycodone-induced hyperlocomotion and locomotor sensitization in mouse models. VK4-116 with pretreatment also inhibits the acquisition of Oxycodone-induced conditioned place preference (CPP) in rat models[1].
Product Specifications
CAS Number
1982347-43-2
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC2=C(N1)C=CC=C2)NCCC(CN3CCN(CC3)C4=CC(CC)=CC(Cl)=C4OC)O
Molecular Formula
C26H33ClN4O3
Molecular Weight
485.02
References & Citations
[1]Kumar V, et al. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem. 2016 Aug 25;59 (16) :7634-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D3 Receptor
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