BMS-952048
BMS-952048 is a positive allosteric modulator of mGluR5 with an EC50 of 10 nM[1].
Product Specifications
CAS Number
1375751-32-8
UNSPSC
12352005
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
Molecular Formula
C21H13F2N3O2
Molecular Weight
377.34
References & Citations
[1]Huang, H., et al., (2016) . Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box. Bioorganic & medicinal chemistry letters, 26 (17), 4165-4169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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