KW-2581

KW-2581 is a steroidal selective steroid sulfatase (STS) inhibitor with an IC50 of 4 nM. KW-2581 inhibits STS activity of ZR-75-1 cells with an IC50 of 13 nM. KW-2581 inhibits the E1S-stimulated growth of ZR-75-1 cells with an IC50 of 0.18 nM. KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells both in vitro and in vivo. KW-2581 induced regression in E1S-induced tumor growth. KW-2581 can be studied in research on hormone receptors-positive breast cancer[1][2].

Product Specifications

CAS Number

[284045-56-3]

UNSPSC

12352005

Target

Steroid Sulfatase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(OC1=CC=C2[C@@]3([H])CC[C@]4(C)C(C(N(C(C)C)C(C)C)=O)=CC[C@@]4([H])[C@]3([H])CCC2=C1)(N)=O

Molecular Formula

C25H36N2O4S

Molecular Weight

460.63

References & Citations

[1]Ishida, H., et al ., (2007) . Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo. Breast cancer research and treatment, 104 (2), 211-219. |[2]Ishida, H., et al., (2007) . A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Breast cancer research and treatment, 106 (2), 215-227.