SC-68448
SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM) . SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors[1][2].
Product Specifications
CAS Number
188804-07-1
Product Name Alternative
S 448
UNSPSC
12352005
Target
Integrin
Related Pathways
Cytoskeleton
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(O)CC(NC(CNC(C1=CC=CC(NC(N)=N)=C1)=O)=O)C2=CC(Cl)=CC(Cl)=C2
Molecular Formula
C19H19Cl2N5O4
Molecular Weight
452.29
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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