SC-68448

SC-68448 (S 448) is a selective αvβ3 antagonist (IC50 = 1 nM) . SC-68448 inhibits αvβ3-mediated endothelial cell proliferation. SC-68448 reduces the total level of αvβ6 in NHBE cells. SC-68448 inhibits angiogenesis in a rat corneal neoplasia model. SC-68448 inhibits tumor growth and completely prevents the development of hypercalcemia in a rat Ledich cell tumor model. SC-68448 can be used in research on cardiovascular and cerebrovascular diseases such as hypercalcemia and cancers such as testicular interstitial cell tumors[1][2].

Product Specifications

CAS Number

[188804-07-1]

Product Name Alternative

S 448

UNSPSC

12352005

Target

Integrin

Related Pathways

Cytoskeleton

Field of Research

Cancer; Cardiovascular Disease

Smiles

O=C(O)CC(NC(CNC(C1=CC=CC(NC(N)=N)=C1)=O)=O)C2=CC(Cl)=CC(Cl)=C2

Molecular Formula

C19H19Cl2N5O4

Molecular Weight

452.29

References & Citations

[1]Carron CP, et al. A peptidomimetic antagonist of the integrin alpha (v) beta3 inhibits Leydig cell tumor growth and the development of hypercalcemia of malignancy. Cancer Res. 1998 May 1;58 (9) :1930-5.|[2]Roper JA, et al. Downregulation of the αvβ6 Integrin via RGD Engagement Is Affinity and Time Dependent. J Pharmacol Exp Ther. 2021 Feb;376 (2) :273-280.