VU6001221
VU6001221 is a blood-brain barrier permeable Choline Transporter (CHT) inhibitor (IC50 = 270 nM) . VU6001221 increases the likelihood of extracellular choline elevation activating synaptic α7 nicotine ACh receptors. VU6001221 attenuates potassium-induced ACh levels in the prefrontal cortex[1][2].
Product Specifications
CAS Number
[2002495-17-0]
UNSPSC
12352005
Target
Others
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(NCC1=CC(C(C)C)=NO1)C2=CC=C(Cl)C(OC3CCN(C)CC3)=C2
Molecular Formula
C20H26ClN3O3
Molecular Weight
391.89
References & Citations
[1]Bertron JL, et al. Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound. Bioorg Med Chem Lett. 2016 Oct 1;26 (19) :4637-4640. |[2]Koshy Cherian A, et al. Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. J Neurosci. 2017 Mar 15;37 (11) :2947-2959.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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