Pelubiprofen (Standard)
Pelubiprofen (Standard) is the analytical standard of Pelubiprofen. This product is intended for research and analytical applications. Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC50 values of 10.66 and 2.88 μM for COX-1 and COX-2, respectively) . Pelubiprofen has significant anti-inflammatory and analgesic effects[1][2].
Product Specifications
CAS Number
69956-77-0
UNSPSC
12352100
Target
COX; IKK; MAP3K; NF-κB; NO Synthase; Reference Standards
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(O)C(C)C1=CC=C(/C=C2C(CCCC/2)=O)C=C1
Molecular Formula
C16H18O3
Molecular Weight
258.31
References & Citations
[1]Choi IA, Baek HJ, et al. Comparison of the efficacy and safety profiles of a pelubiprofen versus celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, phase III, non-inferiority clinical trial. BMC Musculoskelet Disord. 2014 Nov 18;15:375.|[2]Ji-Sun Shin, et al. Anti-inflammatory effect of pelubiprofen, 2-[4- (oxocyclohexylidenemethyl) -phenyl]propionic acid, mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF-κB inactivation. J Cell Biochem. 2011 Dec;112 (12) :3594-603.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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