MK-7288
MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT) . MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) [1][2].
Product Specifications
CAS Number
936626-07-2
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C([C@@H]1CC[C@]2(C3=CC=C(OC)N=C3C(O2)=O)CC1)N(C)CCN4CCCCC4
Molecular Formula
C22H31N3O4
Molecular Weight
401.50
References & Citations
[1]Sun H, et al. Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol. 2013 Dec;53 (12) :1294-302.|[2]Neshat SS, et al. Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review. Sleep Med Rev. 2024 Aug;76:101934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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