MK-7288

MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT) . MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) [1][2].

Product Specifications

CAS Number

[936626-07-2]

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C([C@@H]1CC[C@]2(C3=CC=C(OC)N=C3C(O2)=O)CC1)N(C)CCN4CCCCC4

Molecular Formula

C22H31N3O4

Molecular Weight

401.50

References & Citations

[1]Sun H, et al. Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol. 2013 Dec;53 (12) :1294-302.|[2]Neshat SS, et al. Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review. Sleep Med Rev. 2024 Aug;76:101934.