MK-8325
MK-8325 (Compound 1) is an orally active HCV NS5A inhibitor. MK-8325 exhibits minimal inhibitory activity against hERG at a concentration of 30 mM. MK-8325 may be used in hepatitis C research[1].
Product Specifications
CAS Number
1334312-52-5
UNSPSC
12352005
Target
HCV
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(OC)N[C@@H](C(C)C)C(N1C[Si](C)(C)C[C@H]1C2=NC3=CC=C4C=C(C5=CC=C(C6=CN=C([C@H]7N(C([C@H](C(C)C)NC(OC)=O)=O)CC(F)(F)C7)N6)C=C5)C=CC4=C3N2)=O
Molecular Formula
C43H52F2N8O6Si
Molecular Weight
843.01
References & Citations
[1]Nair AG, et al. MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018 Jun 1;28 (10) :1954-1957.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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