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SB-699393

B-699393 (Compound 17) is a BRAF inhibitor (Kd = 7.2 nM) that can cross the blood-brain barrier. SB-699393 can be used for research on stroke[1].

Product Specifications

CAS Number

502638-39-3

UNSPSC

12352005

Target

Raf

Related Pathways

MAPK/ERK Pathway

Field of Research

Cardiovascular Disease

Smiles

O/N=C1C2=CC=C(C3=C(C4=CC=NC=C4)OC(CN5CCOCC5)=C3)C=C2CC/1

Molecular Formula

C23H23N3O3

Molecular Weight

389.45

References & Citations

[1]Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18 (15) :4373-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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