SB-699393
B-699393 (Compound 17) is a BRAF inhibitor (Kd = 7.2 nM) that can cross the blood-brain barrier. SB-699393 can be used for research on stroke[1].
Product Specifications
CAS Number
[502638-39-3]
UNSPSC
12352005
Target
Raf
Related Pathways
MAPK/ERK Pathway
Field of Research
Cardiovascular Disease
Smiles
O/N=C1C2=CC=C(C3=C(C4=CC=NC=C4)OC(CN5CCOCC5)=C3)C=C2CC/1
Molecular Formula
C23H23N3O3
Molecular Weight
389.45
References & Citations
[1]Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18 (15) :4373-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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