MK-1832
MK-1832 (Compound 32) is a selective Kv1.5 inhibitor (IC50 = 86 nM) . MK-1832 is a P-glycoprotein substrate. MK-1832 can be used in atrial fibrillation research[1].
Product Specifications
CAS Number
935868-50-1
UNSPSC
12352005
Target
P-glycoprotein; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O[C@@H](C1=CC=CN=C1C2=CC(Cl)=CC(Cl)=C2)C(C3=CC=CN=C3)C4=CC=CN=C4
Molecular Formula
C23H17Cl2N3O
Molecular Weight
422.31
References & Citations
[1]Wolkenberg SE, et al. Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics. Bioorg Med Chem Lett. 2017 Feb 15;27 (4) :1062-1069.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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