RWJ-49815

RWJ-49815 is a histidine kinase inhibitor (IC50 = 1.6 uM) . RWJ-49815 inhibits the autophosphorylation of kinase A in the KinA-Spo0F two-component signal transduction system in vitro. RWJ-49815 inhibits the growth of bacteria such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. RWJ-49815 also inhibits the growth of Fungal such as Saccharomyces cerevisiae and Candida albicans[1][2].

Product Specifications

CAS Number

[193282-45-0]

UNSPSC

12352005

Target

Bacterial; Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

NC(NCCC1=CC=C(OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)=N

Molecular Formula

C30H31N3O

Molecular Weight

449.59

References & Citations

[1]Barrett JF, et al. Antibacterial agents that inhibit two-component signal transduction systems. Proc Natl Acad Sci U S A. 1998 Apr 28;95 (9) :5317-22.|[2]Deschenes RJ, et al. Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors. Antimicrob Agents Chemother. 1999 Jul;43 (7) :1700-3.