BAY 41-2272 (Standard)
BAY 41-2272 (Standard) is the analytical standard of BAY 41-2272. This product is intended for research and analytical applications. BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2].
Product Specifications
CAS Number
256376-24-6
UNSPSC
12352100
Target
Guanylate Cyclase; Reference Standards
Related Pathways
GPCR/G Protein; Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5
Molecular Formula
C20H17FN6
Molecular Weight
360.39
References & Citations
[1]Makrynitsa GI, et al. Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme. Front Cell Dev Biol. 2022 Jun 17;10:925457. |[2]Vogel J, et al. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension. Hypertens Res. 2021 Dec;44 (12) :1568-1577.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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