BMS-846372
BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM) . BMS-846372 may be used in migraine research[1][2].
Product Specifications
CAS Number
1190363-03-1
UNSPSC
12352005
Target
CGRP Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64
Molecular Formula
C28H27F2N5O3
Molecular Weight
519.54
References & Citations
[1]Leahy DK, et al. Efficient and scalable enantioselective synthesis of a CGRP antagonist. Org Lett. 2012 Sep 21;14 (18) :4938-41.|[2]Luo G, et al. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. ACS Med Chem Lett. 2012 Feb 27;3 (4) :337-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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