BMS-846372

BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM) . BMS-846372 may be used in migraine research[1][2].

Product Specifications

CAS Number

[1190363-03-1]

UNSPSC

12352005

Target

CGRP Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64

Molecular Formula

C28H27F2N5O3

Molecular Weight

519.54

References & Citations

[1]Leahy DK, et al. Efficient and scalable enantioselective synthesis of a CGRP antagonist. Org Lett. 2012 Sep 21;14 (18) :4938-41.|[2]Luo G, et al. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. ACS Med Chem Lett. 2012 Feb 27;3 (4) :337-41.