Tauro-obeticholic acid-d5

Tauro-obeticholic acid-d5 is deuterium labeled Tauro-obeticholic acid (HY-135399) . Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist[1][2].

Product Specifications

UNSPSC

12352211

Target

Drug Metabolite; FXR; Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Smiles

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](C([2H])([2H])C([2H])([2H])[2H])[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C28H44D5NO6S

Molecular Weight

532.79

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Xiaojiao Li, et al. Comparison of the Pharmacokinetics of Generic Versus Branded Obeticholic Acid in a Chinese Population: Effects of Food and Sex. Clin Pharmacol Drug Dev. 2021 Jul;10 (7) :797-806.