KR-33028
KR-33028 is a selective NHE1 inhibitor. KR-33028 reduces hypoxia-induced necrosis and apoptosis in H9c2 cells. KR-33028 inhibits hypoxia-induced increases in cytoplasmic and mitochondrial Ca2+ levels and cytochrome c release. KR-33028 improves cardiac contractility, reduces lactate dehydrogenase release, and increases tissue ATP, creatine phosphate, and glycogen levels. KR-33028 can be used in research on cancers such as cardioblastoma and cardiovascular diseases such as ischemic stroke[1][2].
Product Specifications
CAS Number
861218-37-3
UNSPSC
12352005
Target
Apoptosis; Na+/H+ Exchanger (NHE)
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Smiles
O=C(C1=CC2=C(C#N)C=CC=C2S1)NC(N)=N
Molecular Formula
C11H8N4OS
Molecular Weight
244.27
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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