Tpl2 Kinase Inhibitor 1 (hydrochloride)
Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM) . Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].
Product Specifications
CAS Number
2934185-09-6
UNSPSC
12352005
Target
MAP3K; MAPKAPK2 (MK2) ; p38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Smiles
FC1=CC=C(NC2=C(C=NC3=C2C=C(NCC4=CN=CC=C4)N=C3)C#N)C=C1Cl.Cl
Molecular Formula
C21H15Cl2FN6
Molecular Weight
441.29
References & Citations
[1]Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15 (23) :5288-92. |[2]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K8/COT/Tpl2; p38 MAPK
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