Tpl2 Kinase Inhibitor 1 (hydrochloride)

Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM) . Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].

Product Specifications

CAS Number

[2934185-09-6]

UNSPSC

12352005

Target

MAP3K; MAPKAPK2 (MK2) ; p38 MAPK

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer; Inflammation/Immunology

Smiles

FC1=CC=C(NC2=C(C=NC3=C2C=C(NCC4=CN=CC=C4)N=C3)C#N)C=C1Cl.Cl

Molecular Formula

C21H15Cl2FN6

Molecular Weight

441.29

References & Citations

[1]Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15 (23) :5288-92. |[2]Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59 (16) :7544-60.