L-783277

L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM) . L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma[1][2].

Product Specifications

CAS Number

[791807-02-8]

UNSPSC

12352005

Target

FLT3; MEK; PDGFR; VEGFR

Related Pathways

MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O

Molecular Formula

C19H24O7

Molecular Weight

364.39

References & Citations

[1]Kim Y, et al. Natural and Synthetic Lactones Possessing Antitumor Activities. Int J Mol Sci. 2021 Jan 21;22 (3) :1052.|[2]Lawnicka H, et al. Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22 (4) :889-95.