L-783277
L-783277 (Compound 4) is a MEK inhibitor (IC50 = 4 nM) . L-783277 has potent inhibitory activity against a variety of kinases, including VEGFR2/3, FLT1/3/4, MEK1/2, KDR, and PDGFRα, but has low selectivity for the kinase community. L-783277 inhibits viability (IC50 = 22 mM) and cell proliferation (IC50 = 21 mM) of H295R cells. L-783277 could be used in research on cancers such as adrenocortical carcinoma[1][2].
Product Specifications
CAS Number
791807-02-8
UNSPSC
12352005
Target
FLT3; MEK; PDGFR; VEGFR
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(O[C@@H](C)C/C=C\1)C2=C(O)C=C(OC)C=C2CCC[C@H](O)[C@H](O)C1=O
Molecular Formula
C19H24O7
Molecular Weight
364.39
References & Citations
[1]Kim Y, et al. Natural and Synthetic Lactones Possessing Antitumor Activities. Int J Mol Sci. 2021 Jan 21;22 (3) :1052.|[2]Lawnicka H, et al. Resorcylic acid lactone L-783,277 inhibits the growth of the human adrenal cancer cell line H295R in vitro. Int J Immunopathol Pharmacol. 2009 Oct-Dec;22 (4) :889-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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