SNAP8719 (free base)

SNAP8719 free base is a selective α1D-adrenoceptor antagonist (pKi = 8.89) . SNAP8719 free base shows affinity for the dopamine D2-, 5-HT1A-, and the human clonal α2a-adrenoceptor, with pKi values of 5.98, 6.47, and [1].

Product Specifications

CAS Number

[255893-38-0]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor; Dopamine Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Smiles

O=C(N([C@H](C)CN1CCN(C2=CC(F)=C(F)C=C2F)CC1)C(C3)=O)CC43CCCC4

Molecular Formula

C22H28F3N3O2

Molecular Weight

423.47

References & Citations

[1]Buckner SA, et al. A-315456: a selective alpha (1D) -adrenoceptor antagonist with minimal dopamine D (2) and 5-HT (1A) receptor affinity. Eur J Pharmacol. 2001 Dec 14;433 (1) :123-7.