CGP-45688

CGP-45688 is an orally active non-steroidal aromatase inhibitor with an ED50 of 30-100 μg/kg. CGP-45688 can reduce the level of estrogen in the body, thereby inhibiting the growth of estrogen-dependent tumors. CGP-45688 inhibits the growth of estrogen-dependent breast tumors in rat models. CGP-45688 disrupts the ovarian cycle and inhibits the weight of the uterus. CGP-45688 can be used for the study of breast cancer[1].

Product Specifications

CAS Number

[134520-88-0]

UNSPSC

12352005

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

N#CC1=CC=C(C(C2=CC=C(C=C2)C#N)N3N=CN=N3)C=C1

Molecular Formula

C16H10N6

Molecular Weight

286.29

References & Citations

[1]Schieweck K, et al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :633-6.