BN-81674
BN-81674 is a somatostatin analogue and a selective antagonist of the non-peptide human somatostatin sst3 receptor (Ki=0.92 nM) . In addition, BN-81674 reversed the inhibition of cyclic AMP accumulation induced by 1 nM somatostatin through the sst3 receptor with an IC50 value of 0.84 nM. BN-81674 can be used in cancer research[1].
Product Specifications
CAS Number
[252278-73-2]
UNSPSC
12352005
Target
Somatostatin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCCCCC1(N[C@H](CC2=C1NC3=C2C=CC=C3)C4=NC=C(N4)C5=CC=CC=C5)CCCCC
Molecular Formula
C30H38N4
Molecular Weight
454.65
References & Citations
[1]Poitout L, et al. Identification of potent non-peptide somatostatin antagonists with sst3 selectivity[J]. Journal of medicinal chemistry, 2001, 44 (18) : 2990-3000.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SSTR3
Curated Selection
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