L-731128
L-731128 is a novel alkyl citrate. L-731128 can be isolated as a minor component of Sporormiella intermedia (MF 5447, ATCC 20985) fermentations. L-731128 is a potent squalene synthase inhibitor, with an IC50 value of 767 nM[1].
Product Specifications
CAS Number
172722-09-7
UNSPSC
12352005
Target
Farnesyl Transferase; Fungal
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
OC(C[C@](C(O)=O)(O)[C@@H](C(O)=O)CCCCC[C@H](C)C[C@H](C)C/C=C/C1=CC=CC=C1)=O
Molecular Formula
C25H36O7
Molecular Weight
448.55
References & Citations
[1]Harris G H, et al. Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B. Bioorganic & Medicinal Chemistry Letters, 1995, 5 (20) : 2403-2408.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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