AP-22161
AP22161 is a potent and selective Src SH2 domain inhibitor with an IC50 of 0.24 µM. AP22161 exhibits >120-fold selectivity over Yes SH2 (IC50 = 29.38 µM) and ZAP SH2 (IC50 = 421.86 µM) . AP22161 inhibits Src-dependent cellular activity and diminishes osteoclast resorptive activity. AP22161 can be used for osteoporosis research[1].
Product Specifications
CAS Number
[268741-42-0]
UNSPSC
12352005
Target
Src
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(O)C1=CC=C(C[C@H](NC(C)=O)C(N[C@H]2CCCCC3=CC(OCC4CCCCC4)=C(C(N)=O)C=C32)=O)C=C1C=O
Molecular Formula
C32H39N3O7
Molecular Weight
577.67
References & Citations
[1]Violette SM, et al. A Src SH2 selective binding compound inhibits osteoclast-mediated resorption. Chem Biol. 2000 Mar;7 (3) :225-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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